Transactions 2010 Through Monday, April 5th
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| Team Name | Replaced | Picked Up |
| I Like Big Bunts | DL - Jeff Francis | Ricky Romero |
| Winged Buffalo | DL - Jordan Zimmermann | Fausto Carmona |
| Non - Smokers | DL - Scott Kazmir | Tim Wakefield |
| Priory of Yawkey Way | DL - Brad Lidge | Ryan Madson |
| Sultans of Swat | DL - Cliff Lee | Jeremy Bonderman |
| The Bigg Doggs | Minors - Aroldis Chapman | Franklin Morales |
| Camel Jockeys | DL - Daisuke Matsusaka | Homer Bailey |
| A.C.L. | DL - Ted Lilly | Shaun Marcum |
| Iron Men | DL - Ian Kinsler | Clint Barmes |
| BALCO Bombers | DL - Brandon Webb | Zach Duke |
| BALCO Bombers | Released - Carlos Ruiz | Ivan Rodriguez |
| Iron Men | DL - Lance Berkman | Jake Fox |
| A.C.L. | DL - Huston Street | Gio Gonzalez |
| Camel Jockeys | DL - Joe Nathan | Justin Masterson |
| The Bigg Doggs | Minors - Buster Posey | Gerald Laird |
| Sultans of Swat | DL - Erik Bedard | Dontrelle Willis |
| Priory of Yawkey Way | DL - Carlos Beltran | Carlos Gomez |
| Winged Buffalo | Released - Brandon Lyon | Mat Latos |
| Camel Jockeys | DL - Edinson Volquez | Luke Hochevar |
| A.C.L. | DL - Jose Reyes | Ian Desmond |
| Iron Men | Released - Ramon Hernandez | J.R. Towles |
| Camel Jockeys | DL - Alex Gordon | Casey McGehee |
| Non - Smokers | DL - Kerry Wood | Brandon Morrow |
Draft Day Trades:
WWEDD? traded their 1st and 2nd round picks to The Bigg Doggs for their 1st and 2nd round picks.
Camel Jockeys traded David Price to WWEDD? for Stephen Drew.