Transactions 2010 Through Monday, September 27th
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| Team Name | Replaced | Picked Up |
| A.C.L. | DL - Geovany Soto | Humberto Quintero |
| Priory of Yawkey Way | Released - Brandon Inge | Activated - Justin Smoak |
| Reserve Moves | ||
| Iron Men | Taxi - Jaime Garcia | Activated - Brett Cecil |
| WWEDD? | Taxi - Jim Thome | Activated - Jose Lopez |
| The Bigg Doggs | Taxi - Aroldis Chapman | Activated - Mike Pelfrey |
| A.C.L. | Taxi - Ryan Madson | Activated - Barry Enright |
| Winged Buffalo | Taxi - Brian Duensing | Activated - Fernando Rodney |