Transactions 2010 Through Monday, September 6th
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| Team Name | Replaced | Picked Up |
| Priory of Yawkey Way | Released - Vin Mazzaro | Activated - Matt Lindstrom |
| Camel Jockeys | Released - Mike Lowell | Activated - Ian Kinsler |
| A.C.L. | DL - Ian Stewart | No Open Spot |
| A.C.L. | Released - Trevor Hoffman | Activated - Dallas Braden |
| Reserve Moves | ||
| BALCO Bombers | Taxi - Nyjer Morgan | Activated - Jonny Gomes |
| Sultans of Swat | Taxi - Johnny Damon | Activated - Matt LaPorta |
| Reversal of Fortune | Taxi - Marco Scutaro | Activated - Jose Reyes |
| Reversal of Fortune | Taxi - Alfredo Simon | Activated - Jeff Niemann |
| Winged Buffalo | Taxi - Manny Ramirez | Activated - Alex Rodriguez |
| Winged Buffalo | Taxi - Cliff Lee | Activated - Jason Hammel |
| Non - Smokers | Taxi - Scott Podsednik | Activated - Dexter Fowler |
| Non - Smokers | Taxi - Leo Nunez | Activated - John Lackey |
| Non - Smokers | Taxi - Brandon Morrow | Activated - Bud Norris |
| A.C.L. | Taxi - Ryan Dempster | Activated - Barry Enright |