Transactions 2010 Through Monday, August 23rd
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| Team Name | Replaced | Picked Up |
| Priory of Yawkey Way | DL - Carlos Guillen | Yuniesky Betancourt |
| BALCO Bombers | Minors - J.P. Arencibia | John Buck |
| Sultans of Swat | DL - Kevin Slowey | Bronson Arroyo |
| Reversal of Fortune | Released - Ronny Paulino | Josh Thole |
| A.C.L. | Released- Barry Zito | Dallas Braden |
| WWEDD? | DL - Dustin Pedroia | Jim Thome |
| Winged Buffalo | DL - Alex Rodriguez | Russell Branyan |
| Priory of Yawkey Way | DL - Matt Lindstrom | Jake Westbrook |
| BALCO Bombers | Released - Jerry Hairston Jr. | Alcides Escobar |
| Priory of Yawkey Way | Released - Clint Barmes | Blake DeWitt |
| Sultans of Swat | Released - Alberto Callaspo | J.D. Drew |
| WWEDD? | Released - J.J. Putz | Activated - Jonathan Broxton |
| Sultans of Swat | DL - Troy Glaus | Kevin Kouzmanoff |
| The Bigg Doggs | Released - Jonathan Lucroy | Activated - Rod Barajas |
| The Bigg Doggs | Released - Chris Johnson | Activated - Chase Headley |
| Camel Jockeys | Released - Edwin Encarnacion | Activated - Mike Lowell |
| Camel Jockeys | Released - Michael Wuertz | Activated - Aaron Bailey |
| The Bigg Doggs | DL - Stephen Strasburg | Randy Wolf |
| Non - Smokers | Released - Bill Hall | Activated - Ryan Howard |
| I Like Big Bunts | Released - Tyler Clippard | No Open Spot |
| Reserve Moves | ||
| The Bigg Doggs | Reserved - Ryan Theriot | Activated - Martin Prado |
| A.C.L. | Reserved - Yunel Escobar | Activated - Eric Young Jr. |
| A.C.L. | Reserved - Francisco Liriano | Brandon Lyon |
| Sultans of Swat | Reserved - John Lackey | Activated - Travis Wood |
| Camel Jockeys | Reserved - Ricky Nolasco | Jeremy Guthrie |
| Non - Smokers | Reserved - Scott Podsednik | Jose Guillen |
| Non - Smokers | Reserved - Kevin Gregg | Bud Norris |