Transactions 2010 Through Monday, June 28th
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Trades: A.C.L. traded Andrew McCutchen and Russell Branyan to the Iron Men for Paul Konerko.
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| Team Name | Replaced | Picked Up |
| BALCO Bombers | Released - Wade Davis | Jhoulys Chacin |
| Iron Men | Released - Jon Niese | Kris Medlen |
| A.C.L. | Released - Alex Gonzalez | Mike Aviles |
| WWEDD? | DL - Dustin Pedrioa | Activated - Jimmy Rollins |
| Camel Jockeys | Released - Carlos Zambrano | Ricky Nolasco |
| BALCO Bombers | Released - Brett Cecil | Dallas Braden |
| BALCO Bombers | Released - Hisanori Takahashi | Activated - Jair Jurrjens |
| BALCO Bombers | Released - Edgar Renteria | No Open Spot |
| Iron Men | Released - Andres Torres | No Open Spot |
| I Like Big Bunts | Released - Scott Kazmir | Activated - Chad Billingsley |
| I Like Big Bunts | Released - Seth Smith | Activated - Austin Jackson |
| I Like Big Bunts | Released - Kevin Kouzmanoff | Activated - J.D. Drew |
| The Bigg Doggs | Released - Wade LeBlanc | Daniel Bard |
| The Bigg Doggs | Released - Alcides Escobar | Activated - Ryan Theriot |
| A.C.L. | DL - Victor Martinez | Jonathan Lucroy |
| A.C.L. | Released - Johnny Damon | No Open Spot |
| A.C.L. | Open Spot | Activated - Juan Rivera |
| BALCO Bombers | Released - Ivan Rodriguez | Promoted - Carlos Santana |
| Winged Buffalo | Released - Luke Gregerson | Activated - Phil Hughes |
| Iron Men | Released - Jake Fox | No Open Spot |
| Reversal of Fortune | Released - Ben Sheets | No Open Spot |
| Reserve Moves | ||
| BALCO Bombers | Reserved - Placido Polanco | Activated - Jason Bartlett |
| Camel Jockeys | Reserved - Nick Hundley | Jason Varitek |
| Camel Jockeys | Reserved - Edwin Jackson | Matt Thornton |
| Non - Smokers | Reserved - Kerry Wood (2nd time) | Tommy Hunter |
| Iron Men | Reserved - Bobby Jenks (2nd time) | Brandon League |
| I Like Big Bunts | Reserved - Neil Walker | Orlando Hudson |
| I Like Big Bunts | Reserved - Erick Aybar | Yuniesky Betancourt |
| A.C.L. | Reserved - Chipper Jones | Activated - Aramis Ramirez |
| BALCO Bombers | Reserved - Clay Buchholz | Mark Buehrle |