Transactions 2007 Through Monday, June 4th
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Trades:
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| Team Name | Replaced | Picked Up |
| Rooster Rage | Released - Matt Morris | Roger Clemens |
| HGH | Released - Joe Crede | Dustin Pedroia |
| HGH | Released - Braden Looper | Activated - Jason Schmidt |
| Iron Men | Released - Angel Guzman | Boof Bonser |
| Priory of Yawkey Way | Released - Solomon Torres | Brad Hennessey |
| Winged Buffalo | Released - Jeff Suppan | Jeff Francis |
| The Bigg Doggs | Released - Sergio Mitre | Matt Capps |
| Non - Smokers | Released - Ryan Madson | Activated - Jason Jennings |
| Non - Smokers | Released - Ryan Church | Activated - Reggie Willits |
| Iron Men | DL - Ryan Freel | Randy Winn |
| Priory of Yawkey Way | DL - Chipper Jones | Mark Reynolds |
| The Bigg Doggs | Released - Felipe Lopez | Luis Castillo |
| Iron Men | DL - Rickie Weeks | Alex Gonzalez |
| A.C.L. | Released - Tadahito Iguchi | Activated - Ryan Howard |
| A.C.L. | Released - Daniel Cabrera | No Open Spot |
| Priory of Yawkey Way | Released - Jack Cust | Kaz Matsui |
| Sultans of Swat | DL - Lyle Overbay | Pedro Feliz |
| Camel Jockeys | Released - Scott Baker | Activated - Orlando Hernandez |
| Winged Buffalo | Released - Jeremy Hermida | No Open Spot |
| Winged Buffalo | Released - Austin Kearns | Activated - Josh Hamilton |
| Winged Buffalo | Released - Placido Polanco | No Open Spot |
| Non - Smokers | Released - Tim Wakefield | No Open Spot |
| Reserve Moves | ||
| The Bigg Doggs | Reserved - Chris Duncan | Jim Edmonds |
| Iron Men | Reserved - Akinori Otsuka | Paul Byrd |
| A.C.L. | Reserved - Fausto Carmona | Brad Lidge |
| Winged Buffalo | Reserved - Chris Ray | Activated - Octavio Dotel |
| Non - Smokers | Reserved - Corey Patterson | Melky Cabrera |