Transactions 2007 Through Monday, April 16th
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| Team Name | Replaced | Picked Up |
| Iron Men | DL - B.J. Ryan | Jason Frasor |
| A.C.L. | Released - Milton Bradley | Akinori Iwamura |
| Sultans of Swat | DL - Carl Pavano | Gil Meche |
| The Bigg Doggs | Released - Zach Duke | Joakim Soria |
| Priory of Yawkey Way | Released - Bobby Crosby | Activated - Chipper Jones |
| Make 7up Yours | DL - Kelvim Escobar | Greg Maddux |
| Rooster Rage | Released - Scott Thorman | Melvin Mora |
| Camel Jockeys | Released - Jonny Gomes | Macier Izturis |
| HGH | Released - Oliver Perez | Micah Owings |
| Non - Smokers | Released - Ryan Shealy | Ryan Garko |
| Non - Smokers | Released - Greg Zaun | Activated - Victor Martinez |
| HGH | DL - Ramon Hernandez | Carlos Ruiz |
| Rooster Rage | DL - Mike Mussina | Matt Belisle |
| Priory of Yawkey Way | DL - Josh Bard | Brian Schneider |
| The Bigg Doggs | Released - Jose Lopez | Activated - Freddy Sanchez |
| Sultans of Swat | Released - Jorge Julio | Kyle Lohse |
| A.C.L. | Released - Fausto Carmona | Ramon Ortiz |
| Iron Men | Released - Scot Shields | Henry Owens |
| HGH | Released - Elijah Dukes | Moises Alou |
| Sultans of Swat | Reserved - Jason Hirsh | Activated - Freddy Garcia |
| The Bigg Doggs | Reserved - Aramis Ramirez | Casey Kotchman |
| Camel Jockeys | Released - David Riske | Activated - Eric Gagne |
| Camel Jockeys | Reserved - Mark Buerhle | Braden Looper |
| Non - Smokers | DL - Jason Jennings | Jeff Francis |
| Non - Smokers | Reserved - Corey Patterson | Luis Gonzalez |
| Iron Men | Released - Kip Wells | Activated - Jered Weaver |
| Iron Men | Released - Troy Tulowitzki | Aaron Hill |
| Priory of Yawkey Way | DL - Troy Glaus | Andy Marte |
| A.C.L. | Released - Brad Lidge | No Open Spot |