Transactions 2006 Through Monday, May 15th
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| Team Name | Replaced | Picked Up |
| Priory of Yawkey Way | Released - Cory Lidle | Brandon McCarthy |
| Iron Men | Released - Nate Robertson | Dan Wheeler |
| Rooster Rage | Released - Omar Vizquel | Ryan Zimmerman |
| A.C.L. | Released - Sean Marshall | Tony Armas Jr. |
| Harpooners | DL - Moises Alou | Reed Johnson |
| Camel Jockeys | Released - Craig Wilson | Adam LaRoche |
| Make 7up Yours | DL - Hideki Matsui | Bubba Crosby |
| Winged Buffalo | DL - Brian Schneider | Brad Ausmus |
| Asian Pranksters | DL - Aaron Rowand | Kenny Lofton |
| Sultans of Swat | Released - Todd Walker | Luis Castillo |
| Rooster Rage | Released - Clint Barmes | Adrian Beltre |
| Make 7up Yours | Released - Joel Pineiro | Tyler Walker |
| Make 7up Yours | Released - Phil Nevin | Activated - Aubrey Huff |
| Non - Smokers | Released - Vicente Padilla | Activated - Jason Isringhausen |
| Non - Smokers | Released - Ty Wiggington | Activated - Ken Griffey Jr. |
| Non - Smokers | Released - Joe Blanton | No Open Spot |
| A.C.L. | Released - David Ross | Activated - Javy Lopez |
| The Bigg Doggs | Released - Matt Cain | No Open Spot |
| The Bigg Doggs | Released - Gustavo Chacin | Promoted - Cole Hamels |
| Sultans of Swat | DL - Jose Contreras | Activated - C.C. Sabathia |
| A.C.L. | Reserved - Kyle Davie | Francisco Cordero |
| Camel Jockeys | DL - Daniel Cabrera | Chad Qualls |
| Winged Buffalo | Reserved - Brad Penny | Jeff Suppan |
| Winged Buffalo | Released - Woody Williams | Jake Westbrook |
| Winged Buffalo | Released - Odalis Perez | No Open Spot |
| Winged Buffalo | Released - Juan Uribe | No Open Spot |
| A.C.L. | Released - Humberto Cota | John Buck |
| Camel Jockeys | DL - Ben Sheets | Taylor Buchholz |
| Rooster Rage | DL - Gary Sheffield | No Open Spot |
| Rooster Rage | Released - Livan Hernandez | Chan Ho Park |
| A.C.L. | Released - Dmitri Young | No Open Spot |
| A.C.L. | Released - Ryan Doumit | No Open Spot |