Transactions 2006 Through Monday, August 21st
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| Team Name | Replaced | Picked Up |
| Priory of Yawkey Way | DL - Eddie Guardado | Justin Duchscherer |
| Rooster Rage | Released - Gary Matthews Jr. | Lyle Overbay |
| Non - Smokers | Released - Brad Lidge | Daniel Cabrera |
| Asian Pranksters | Reserved - Jeff Kent | Activated - Robinson Cano |
| The Bigg Doggs | Minors - Anthony Reyes | Joel Zumaya |
| Iron Men | DL - Huston Street | Chad Billingsley |
| Sultans of Swat | DL - Pedro Martinez | Ian Snell |
| Rooster Rage | Released - Gil Meche | Jon Garland |
| Rooster Rage | Released - Jay Gibbons | No Open Spot |
| The Bigg Doggs | Released - Ambiorix Burgos | Joe Blanton |
| Iron Men | Released - Jason Davis | Chuck James |
| Winged Buffalo | Reserved - Kevin Mench | Brian Giles |
| Priory of Yawkey Way | Released - BJ Upton | Activated - Nomar Garciaparra |
| Priory of Yawkey Way | Released - Shin-Soo Choo | Chris Duncan |
| A.C.L. | Reserved - Brian Fuentes | Dan Wheeler |
| A.C.L. | Reserved - Brandon Webb | Kyle Lohse |
| Non - Smokers | Reserved - Tom Gordon | Kiko Calero |
| Winged Buffalo | Released - Mike Napoli | No Open Spot |
| Rooster Rage | Reserved - Mike Mussina | Miguel Batista |
| A.C.L. | Released - Chan Ho Park | No Open Spot |
| Priory of Yawkey Way | Released - Mike Sweeney | No Open Spot |