Transactions 2006 Through Monday, April 10th
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| Team Name | Replaced | Picked Up |
| Sultans of Swat | Released - Jae Seo | Danys Baez |
| The Bigg Doggs | DL - Noah Lowry | Brandon Backe |
| Iron Men | Released - Daniel Cabrera | David Bush |
| Priory of Yawkey Way | DL - Julio Lugo | J.J. Hardy |
| Asian Pranksters | DL - Eric Gagne | Rafael Soriano |
| Sultans of Swat | DL - C.C. Sabathia | Bronson Arroyo |
| Sultans of Swat | Released - Casey Kotchman | Activated - Mike Lowell |
| Priory of Yawkey Way | Released - Craig Wilson | Ryan Langerhans |
| Asian Pranksters | Released - Dan Johnson | Aaron Boone |
| A.C.L. | DL - Nomar Garciaparra | Jason Smith |
| A.C.L. | Released - Corey Patterson | Alexis Rios |
| A.C.L. | Reserved - Aaron Heilman | Orlando Hernandez |
| Iron Men | Released - Scott Baker | Brandon McCarthy |
| Iron Men | Reserved - Kelvim Escobar | Steve Trachsel |
| Iron Men | Reserved - Coco Crisp | Cory Sullivan |